8550980001 Display Image

(3-FORMYLINDOLYL)ACETAMIDOMETHYL POLYSTYRENE

Code: 8550980001 D2-231

Analysis Note

Color (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (determined by elemental analysis of sulfur after coupling with tosylhydr...


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Your Price
£103.76 EACH

Analysis Note

Color (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (determined by elemental analysis of sulfur after coupling with tosylhydrazide): 0.60 - 1.20 mmol/gSwelling Volume (in DMF): lot specific resultThe polymer matrix is copoly (styrene-1% DVB), 100 - 200 mesh

General description

Versatile indole-based linker for the synthesis of secondary amides, carbamates, ureas [1-4] and aminopurines [5]. In a study comparing the cleavage rates of secondary amides, ureas, carbamates and sulfonamides from indole, dialkoxybenzaldehyde and Rink amide resins, the indole resin was found to be the most acid-labile [6].

Reductive amination with excess of amine and NaBH(OAc)3 in DCE/TMOF [see page], NaBH3CN in THF/TMOF/AcOH, or NaBH4-Ti(OiPr)4 in THF [2], converts the formyl group to the appropriate secondary amine. Cleavage can be effected with 2-5 % TFA in DCM, depending on the nature of the product being released from the resin.

The product number for this product was previously 01-64-0361.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: 01-64-0361

application(s)peptide synthesis
formbeads
functional groupaldehyde
manufacturer/tradenameNovabiochem®
Quality Level200
reaction suitabilityreaction type: Fmoc solid-phase peptide synthesis
storage temp.2-8°C
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8550980005
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List Price: £448.42
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8550980025
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List Price: £2,194.87
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