WH0054961M1-100UG Display Image

Monoclonal Anti-SSH3 antibody produced in mouse, clone 6F9, purified immunoglobulin, buffered aqueous solution

Code: WH0054961M1-100UG D2-231

Biochem/physiol Actions

SSH3 (Slingshot protein phosphatase 3) is involved in the actin filament assembly. During actin reorganization, LIM-kinase 1 (LIMK1) restricts the act...


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£432.00 100UG
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Biochem/physiol Actions

SSH3 (Slingshot protein phosphatase 3) is involved in the actin filament assembly. During actin reorganization, LIM-kinase 1 (LIMK1) restricts the activity of ADF (actin-depolymerizing factor)/cofilin, which is a stimulus-responsive mediator of actin dynamics. SSH3 blocks the LIMK1 functions and reactivates ADF/cofilin in vivo by the dephosphorylating it. In addition, it is also involved in several cellular and developmental activities.

General description

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM

Immunogen

SSH3 (NP_060327, 293 a.a. ~ 391 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceSKEIRQALELRLGLPLQQYRDFIDNQMLLLVAQRDRASRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPH

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Physical form

Solution in phosphate buffered saline, pH 7.4

antibody formpurified immunoglobulin
antibody product typeprimary antibodies
biological sourcemouse
clone6F9, monoclonal
conjugateunconjugated
formbuffered aqueous solution
GenBank® accession no.NM_017857
Gene Informationhuman ... SSH3(54961)
isotypeIgG2aκ
Quality Level100
shipped indry ice
species reactivityhuman
storage temp.−20°C
technique(s)indirect ELISA: suitable, western blot: 1-5 µg/mL, indirect immunofluorescence: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable
UniProt accession no.Q8TE77
This product has met the following criteria: