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Anti-Potassium Channel K2P4.1 (TRAAK) antibody produced in rabbit, affinity isolated antibody, lyophilized powder

Code: K0265-50UL D2-231

Biochem/physiol Actions

The gene KCNK4 (potassium two pore domain channel subfamily K member 4) encodes a potassium channel that is mechanosensitive and is regulated by polyu...


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£290.00 50UL
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Biochem/physiol Actions

The gene KCNK4 (potassium two pore domain channel subfamily K member 4) encodes a potassium channel that is mechanosensitive and is regulated by polyunsaturated fatty acids and temperature. The structure and chemical composition of the lipid bilayer has a profound effect on the functioning of this K+ channel. It is found to regulate the noxious input threshold in dorsal root ganglia neurons.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The gene K2P4.1, also referred to as KCNK4 (potassium two pore domain channel subfamily K member 4), encodes a protein belonging to the subfamily of K2P (two pore domain K+ channel) channels called TRAAK (TWIK-related arachidonic acid-stimulated K+ channel). The TRAAK channels are expressed selectively in the nervous system. TRAAK channel contains two protomers, each with two distinct pore domains forming a two-fold symmetric potassium channel.

Immunogen

peptide NLAFIDESSDTQSERGC, corresponding to amino acid residues 343-359 of human K2P4.1.

Physical form

Lyophilized powder from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

Reconstitution

Reconstitute the lyophilized vial with 50 µL or 200 µL deionized water, depending on package size. Further dilutions should be made using a carrier protein, such as BSA (1-3%).

Specificity

The K2P4.1 antibody is directed against a highly conserved epitope in the intraracellular C-terminal region of the human K2P4.1 channel.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
conjugateunconjugated
formlyophilized powder
Gene Informationhuman ... KCNK4(50801)rat ... Kcnk4(116489)
Quality Level200
species reactivityrat, human
storage temp.−20°C
technique(s)immunohistochemistry: suitable, western blot: 1:200 using HEK-K2P4.1 transfected cells or rat cerebellum lysate
UniProt accession no.Q9NYG8
This product has met the following criteria: