E6376-25G Display Image

Erythromycin, potency: >=850 mug per mg

Code: E6376-25G D2-231

Application

ApplicationErythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed large...


read more

Your Price
£212.00 25G
£254.40 inc. VAT

Application

ApplicationErythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

Biochem/physiol Actions

Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex.Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria.

Caution

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

General description

Chemical structure: macrolide

Packaging

25, 100 g in poly bottle

Preparation Note

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

antibiotic activity spectrumGram-positive bacteria, Gram-negative bacteria
biological sourceStreptomyces erythreus
colorwhite
formpowder
Gene Informationhuman ... ABCB1(5243), CYP3A4(1576), MLNR(2862)mouse ... Abcb1a(18671), Abcb1b(18669)
InChI keyULGZDMOVFRHVEP-RWJQBGPGSA-N
InChI1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
mode of actionprotein synthesis | interferes
potency≥850 µg per mg
Quality Level200
SMILES stringCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
solubilityethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
Code
Description
Unit Size
List Price
Qty
E6376-100G
Unit:100G
List Price: £705.00
Source:List Price
ADD
Cas Number114-07-8
This product has met the following criteria: