Application

Thyrotropic hormone from human pituitary also referred to as TSH can be used as a medium supplement for primary cell culture, and is used further to study the molecular mechanisms of estrogen-mediated growth stimulation of human thyroid tumor cells.

Biochem/physiol Actions

Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Thyrotropic hormone or Thyroid stimulating hormone (TSH) belongs to glycoprotein hormone family. The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.

In children, thyroid hormones are very much essential for the normal cognition andneurodevelopment. Thyroid-stimulating hormone(TSH) test is mainly used to diagnose thyroidfunction.

General description

Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family. Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.

Packaging

Package size based on hormone

Physical form

Contains hormone and salts from approx. 0.1 mL of 0.05 M phosphate buffer, pH 7.4.