Application

Anti-Transferrin antibody produced in goat was used in western blotting analysis of HEK293 cell extracts.

Anti-Transferrin antibody has been used:in quantitative precipitin assayin enzyme linked immunosorbent assay (ELISA)in western blottingin immunoblotting

Biochem/physiol Actions

Transferrin is the major iron transporter protein that binds Fe(+3). The transferring-iron import system consists of a TonB dependent transporter (TbpA), and a lipoprotein co-receptor (TbpB) and both proteins work together in the transport of iron across the membrane.

Transferrin plays a major role in providing iron as a source for haemoglobin synthesis. It binds to the transferrin receptor 1(TfR1).

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General description

Transferrin is a bilobed glycoprotein. The polypeptide chain of transferrin is composed of two homologous lobes i.e N- and C- lobes. Each lobe is made of two domains N₁, N₂ and C₁, C₂ which are linked by a hinge. It has two specific sites for binding of Fe³⁺.

Preparation Note

treated to remove lipoproteins