T1455-5MG Display Image

TNP-470, >=98% (HPLC)

Code: T1455-5MG D2-231

Biochem/physiol Actions

Studies have reported that TNP-470 can decrease intimal neovascularization in Apo-E deficient mice. TNP-470 can also prevent tumor growth in human bre...


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£232.00 5MG
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Biochem/physiol Actions

Studies have reported that TNP-470 can decrease intimal neovascularization in Apo-E deficient mice. TNP-470 can also prevent tumor growth in human breast and prostate cancer cell lines.

TNP-470 is a methionine aminopeptidase-2 (MetAP-2) inhibitor, selective for MetAP-2 over MetAP11. TNP-470 is an antiangiogenic.

Features and Benefits

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

TNP-470 is a synthetic analogue of fumagillin. It is a natural product of Aspergillus fumigatus. TNP-470 serves as an angiogenesis inhibitor.

Other Notes

TNP-470 is hygroscopic.

Packaging

5, 25 mg in glass bottle

Preparation Note

TNP-470 is soluble in DMSO at a concentration that is greater than 15 mg/ml.

assay≥98% (HPLC)
formsolid
InChI keyMSHZHSPISPJWHW-PVDLLORBSA-N
InChI1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
originatorTakeda
Quality Level100
SMILES stringCO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@@]3(C)O[C@@H]3CC=C(C)C)OC(=O)NC(=O)CCl
solubilityDMSO: >15 mg/mL
storage temp.−20°C
Code
Description
Unit Size
List Price
Qty
T1455-25MG
TNP-470, >=98% (HPLC)

Unit:25MG
List Price: £731.00
Source:List Price
ADD
Cas Number129298-91-5
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