Biochem/physiol Actions

Tumor necrosis factor α (TNFα or TNFSF2) is produced by many different cell types including activated monocytes, fibroblasts, endothelial cells, macrophages, T-cells, B-lymphocytes, granulocytes, smooth muscle cells, eosinophilis, chondrocytes and other cell types. It functions as a cytokine involved in cell proliferation, differentiation, apoptosis, lipid metabolism and coagulation. High level of TNFα leads to the development of inflammatory responses that are hallmarks of many diseases including autoimmune diseases, insulin resistance and cancer. The active form of TNFα (18 kDa) is generated by the cleavage of an Ala-Val bond between residues 76-77 of the precursor protein.

General description

Tumor necrosis factor α (TNFα or TNFSF2) is encoded by the gene mapped to human chromosome 6p21.33.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.