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GELDANAMYCIN-FITC

Code: SML1277-1MG D2-231

Biochem/physiol Actions

Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluo...


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£289.00 1MG

Biochem/physiol Actions

Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

General description

Chemical structure: benzenoid

antibiotic activity spectrumneoplastics
assay≥98% (HPLC)
biological sourceStreptomyces hygroscopicus
coloryellow to yellow-orange
formpowder
mode of actionenzyme | inhibits
Quality Level200
solubilityDMSO: soluble 5 mg/mL
storage conditionprotect from light
storage temp.−20°C
Cas Number1320265-38-0
Quantity
Est. Dispatch/Availability