SML0723-25MG Display Image

ML252, >=98% (HPLC)

Code: SML0723-25MG D2-231

Biochem/physiol Actions

ML252 is a potent, brain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor with an IC50 of 69 nM. ML252 is only slightly selective over K...

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£451.58 25MG
List Price

Biochem/physiol Actions

ML252 is a potent, brain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor with an IC50 of 69 nM. ML252 is only slightly selective over KCNQ3 and KCNQ4 but is over 40-fold selective for KCNQ2 vs KCNQ1, unlike other KCNQ inbhibitors currently used. ML252 was also selective vs. >68 tested GPCRs, ion channels, and transporters. Potassium channel Kv7.2 has become a new target for Alzheimer′s Disease drug research because inhibiting it enhances acetylcholine release. SAR studies showed a small structural change from ethyl group to hydrogen resulted in a functional shift from antagonist to agonist activity (37, EC50 of 170 nM), suggesting an interaction at a critical site for controlling KCNQ2 channel gating.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
color, light to dark purple
Quality Level100
storage temp.2-8°C
solubilityDMSO: 25 mg/mL, clear
formpowder

Code
Description
Unit Size
List Price
Qty
SML0723-5MG
Unit:5MG
List Price: £116.57
Source:List Price
ADD
Cas Number1392494-64-2