Application

SU5402 has been used as a fibroblast growth factor receptor inhibitor:in cell signalling experiments to stimulate cells for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assayto study its effect on the expression of osteogenic markers and expression of osteoprotegerin and RANKL (runt-related transcription factor(RUNX)-2to prepare a stock solution with DMSO (Dimethyl superoxide) for cell culture medium and also to co-treat embryosto study its effect on osteogenic markers.

Biochem/physiol Actions

SU-5402 has inhibitory effect on the action of tyrosine kinases. It competitively binds to the ATP-binding site on the fibroblast growth factor receptor (FGFR).

SU-5402 is a FGFR antagonist and angiogenesis inhibitor.

Features and Benefits

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Packaging

5, 25 mg in glass bottle