Biochem/physiol Actions

KIAA0196 (strumpellin) is involved in the WASH (WASP and Scar homologue) complex, an actin-regulating complex. It works as an interlink between actin regulation and endosomal membrane dynamics. Mutations in KIAA0196 are associated with spastic paraplegia and RSS (Ritscher-Schinzel syndrome).

Features and Benefits

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General description

The gene KIAA0196 (strumpellin) is mapped to human chromosome 8q24. It is a widely expressed gene and the protein localizes in the cytoplasm and endoplasmic reticulum.

Immunogen

Antibody was raised against a 19 amino acid peptide near the carboxy terminus of human Strumpellin.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500640.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.