Application

Anti-TIM-1 antibody produced in rabbit has been used in immunofluorescence.

Biochem/physiol Actions

Hepatitis A virus cellular receptor 1 (HAVCR1) regulates susceptibility to human immunodeficiency virus-1 (HIV-1) infection. It is upregulated in injured kidneys. HAVCR1 inhibits the activation of the Ga12 G-protein by blocking its association to GTP. Polymorphisms in the protein have been associated with immune dysfunction.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Hepatitis A virus cellular receptor 1 (HAVCR1) or T-cell immunoglobulin and mucin protein (TIM-1) is a type 1 transmembrane glycoprotein. The protein is found in the apical membrane of cells. It is expressed in the kidney, testis and activated CD4⁺ T-cells. It possesses a six-cysteine immunoglobulin-like domain, a T/SP rich domain and two N-glycosylation sites. The TIM-1 gene is localized on human chromosome 5q33.2.

Immunogen

TIM-1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human TIM-1.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500252.

Physical form

Supplied in PBS with 0.02% sodium azide.