Application

Anti-GPLD1 antibody produced in mouse is suitable for western blot analysis.

Biochem/physiol Actions

GPLD1 (Glycosylphosphatidylinositol specific phospholipase D1) is only expressed in human lver. Inositol phosphate linkage in proteins anchored by phosphatidylinositol-glycans (PI-Gs) is specifically hydrolyzed by GPLD1, suggesting GPLD1 expression might influence the location and expression of PI-G-anchored proteins. Studies have reported that it might be a significant factor in process of leukemia pathogenesis.

General description

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. (provided by RefSeq)

Immunogen

GPLD1 (AAH20748.1, 1 a.a. ~ 176 a.a) full-length human protein.SequenceMSAFRLWPGLLIMLGSLCHRGSPCGLSTHIEIGHRALEFLQLHNGRVNYRELLLEHQDAYQAGIVFPDCFYPSICKGGKFHDVSESTHWTPFLNASVHYIRENYPLPWEKDTEKLVAFLFGITSHMAADVSWHSLGLEQGFLRTMGAIDFHGSYSEAHSAGDFGTVYLHLLNFLVV

Physical form

Solution in phosphate buffered saline, pH 7.4