SAB1403411-100UG Display Image

Monoclonal Anti-SIGLEC12, (C-terminal) antibody produced in mouse, clone 1D1, purified immunoglobulin, buffered aqueous solution

Code: SAB1403411-100UG D2-231

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to b...

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£327.00 100UG
List Price

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. (provided by RefSeq)

Immunogen

SIGLEC12 (NP_443729.1, 503 a.a. ~ 595 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceRSCRKKSARPAVGVGDTGMEDANAVRGSASQGPLIESPADDSPPHHAPPALATPSPEEGEIQYASLSFHKARPQYPQEQEAIGYEYSEINIPK

Physical form

Solution in phosphate buffered saline, pH 7.4

Gene Informationhuman ... SIGLEC12(89858)
clone1D1, monoclonal
shipped indry ice
isotypeIgG2aκ
antibody formpurified immunoglobulin
NCBI accession no.NM_053003
mol wtantigen ~36.34 kDa
application(s)indirect ELISA: suitable
application(s)western blot: 1-5 µg/mL
application(s)capture ELISA: suitable
storage temp.−20°C
Quality Level100
antibody product typeprimary antibodies
UniProt accession no.Q96PQ1
conjugateunconjugated
biological sourcemouse
species reactivityhuman
formbuffered aqueous solution