Biochem/physiol Actions

Sestrin 1 (SESN1) activates AMP-responsive protein kinase (AMPK) which phosphorylates tuberous sclerosis complex 2 (TSC2), and subsequently inhibits mammalian target of rapamycin protein (mTOR). Mutations in the gene encoding the protein have been linked to heterotaxia.

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General description

Sestrin 1 (SESN1) is expressed in the nucleus and is a target gene of the tumor suppressor p53. The gene encoding it is localized on human chromosome 6q21.

Immunogen

SESN1 (NP_055269.1, 1 a.a. ~ 551 a.a) full-length human protein.SequenceMAEGENEVRWDGLCSRDSTTRETALENIRQTILRKTEYLRSVKETPHRPSDGLSNTESSDGLNKLLAHLLMLSKRCPFKDVREKSEFILKSIQELGIRIPRPLGQGPSRFIPEKEILQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEALMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT

Physical form

Solution in phosphate buffered saline, pH 7.4