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The epitope recognized by PLA0299 maps to a region between residue 95 and 145 of human Ribosomal Protein L26 using the numbering given in entry NP_000978.1 (GeneID 6154).
RPL26 is a component of the 60S ribosomal subunit. Ribosomes are composed of a small 40S subunit and a large 60S subunit that function to catalyze protein synthesis. RPL26 is a cytoplasmic protein that functions at the translational level to induce protein expression. RPL26 has been demonstrated to bind the 5’; UTR of p53 mRNA in response to DNA damage. This interaction is described as one of many mechanisms that serve to increase p53 protein levels after DNA damage.
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide