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Immunogen

The epitope recognized by PLA0264 maps to a region between residue 150 and 200 of human Lupus Ku autoantigen protein p86 using the numbering given in entry NP_066964.1 (GeneID 7520).

Other Notes

Ku80 is the 80 kDa subunit of the lupus Ku autoantigen. The lupus Ku autoantigen was identified in individuals with systemic lupus erythematosus (SLE) and related disorders. The Ku antigen is a heterodimer of Ku70 and Ku80. The Ku70/Ku80 complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P13010].

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide