Application

Parthenolide has been used:in the crystallization with vasohibin 1 (VASH1) to study tubulin detyrosination inhibitionas an inhibitor of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) and signal transduction and activation of transcription (STAT) inhibitor to study its effects on the cytoadhesion of CD36-bindingPlasmodium falciparum-infected erythrocytes (IECD36)as a lipophilic agent to study its effects on the production of interleukin?13 and interferon?γ by peripheral blood-derived CD8⁺ T cells

Biochem/physiol Actions

Parthenolide is a sesquiterpene lactone present abundantly in the leaves and flowers of Tanacetum parthenium. It exhibits anti-cancer properties for the treatment of invasive cancers. Parthenolide exhibits therapeutic effects against inflammation and migraine. It plays a role in signal transduction and activation of transcription (STAT)-inhibition-mediated transcriptional repression of pro-apoptotic genes.

Anti-inflammatory agent that inhibits NF-κB activation.

Other Notes

Sesquiterpene lactone found in feverfew (Tanacetum parthenium) and other plants.

Packaging

25 mg in glass bottle

5 mg in glass insert