Analysis Note

relative stereochemistry

Application

Nutlin-3 has been used:as a drug to stimulate p53 functions in gene transfer experimentto inject worms to verify the prevalent role of translationally controlled tumor protein (TCTP) in posterior amputatedE.eugeniaeas a p53 activator in cyclotherapy studiesas an mdm2inhibitor to know its effect on p53 levels, cleavedcaspase 3and Poly (ADP-ribose) polymerase (PARP) cleavage

Biochem/physiol Actions

Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist, p53 pathway activator, and apoptosis inducer.

Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Legal Information

Sold under license from Hoffman-La Roche, Inc. US patent 6,734,302.

Other Notes

Relative stereochemistry; racemic mixture of (4R, 5S) and (4S, 5R) enantiomers.

Packaging

1, 5 mg in glass bottle