Application

PYR-41 has been used as E1 inhibitor:to determine the cellular degradation pathways on adeno-associated viruses (AAV) transductionto assess its selectivity and potency by matrix assisted laser desorption/ionization-time of flight (MALDI-TOF) E2/E3 assayto treat fully differentiated C2C12 myotubes in high glucose medium for determining its effect on protein ubiquitination and cell viabilityin the pretreatment of human brain microvascular endothelial cells (hBMECs) for the inhibition studies before infection with bacteria

Biochem/physiol Actions

PYR-41 inhibits E1 ubiquitin ligases like mouse double minute 2 homolog (MDM2), Itchy (ITCH) and HOIL-1L interacting protein (HOIP). It has anticancer potential.

PYR-41 is a cell permeable inhibitor of Ubiquitin activating enzyme (E1) with little or no activity against E3, E2, or caspase enzymatic activity.

Packaging

5, 25 mg in glass bottle