Biochem/physiol Actions
Muscarinic acetylcholine receptor M2 plays an important role in regulating functions of the heart and processes like pain perception and cognition. It is regarded as a good model in G protein-coupled receptors (GPCR) pharmacological studies. This receptor has a function in airway remodeling and it enhances the proliferation of airway smooth muscle cells (ASM) which is induced by transforming growth factor-β (TGF-β).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Muscarinic acetylcholine receptor M2 is expressed in the heart and many other tissues. The gene encoding it is localized on human chromosome 7.
Immunogen
synthetic peptide corresponding to the third cytoplasmic loop of human muscarinic acetylcholine receptor M2, conjugated to KLH. The immunizing peptide has 100% homology with the mouse and rat gene.
Physical form
Solution in phosphate buffered saline, containing 0.1% sodium azide.
This product has met the following criteria: