Biochem/physiol Actions

Muscarinic acetylcholine receptor M₃ functions as a protectant in myocardial ischemia. It also has roles in smooth muscle contraction and glandular secretion. The receptor has a specific affinity for the G_q/11 family of G proteins.

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General description

Muscarinic acetylcholine receptor M₃ possesses a vestibule which is a part of a hydrophilic channel having a orthosteric binding site.

Immunogen

Synthetic peptide from the third extracellular loop of rat m3 (Accession P08483).

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative.

Specificity

Muscarinic acetylcholine receptor m3.

Target description

Muscarinic Acetylcholine Receptor M₃ controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.