Biochem/physiol Actions

Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase a (MRCKa) is a Cdc42/Rac/Rho interactive/binding serine/threonine kinase with multiple functional domains. MRCK are effectors of RhoA and Cdc42, respectively, for actin reorganization. MRCKa is a critical regulator of signal transduction pathways in eukaryotic cells that are known principally for their role in regulating the cytoskeleton, and they do so by recruiting a variety of downstream effector proteins.

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Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.