Biochem/physiol Actions

Melanocortin 4 receptor (MC4R) is an important regulator of food intake and body weight in mammals. It also regulates energy homeostasis in response to neuropeptides. Polymorphisms in MC4R gene or haploinsufficiency results in early onset obesity in humans also termed melanocortin obesity syndrome.

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Immunogen

synthetic peptide corresponding to the N-terminal extracellular domain of human melanocortin 4 receptor. The immunizing peptide has 94% homology with the rat and mouse gene.

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.