Biochem/physiol Actions

MeCP2 can bind to a single symmetrically methylated CpG pair. It is also capable of binding to chromosomes at sites known to have methylated DNA. MeCP2 silences transcription by recruiting the histone deacetylase (HDAC) repressive machinery via recruitment of the Sin 3A corepressor thus removing acetyl groups from histones and consequently silencing genes.

Methyl-CpG binding protein 2 (MeCP2) has been shown be crucial for brain development. It is part of the methyl-CpG-binding proteins, which are involved in repression of gene expression by binding to methylated DNA. Mutations in the gene encoding MeCP2 have been associated with Rett syndrome (RTT).

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General description

Methyl-CpG binding protein 2 (MeCP2) possesses a methyl-CpG-binding domain (MBD) and a transcriptional repression domain.

Immunogen

synthetic peptide corresponding to the C-terminus of human MeCP2 (amino acids 465-478) conjugated to KLH. The sequence is conserved in rat and mouse.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.