Application

α-(Methylamino)isobutyric acid (MeAIB) has been used:as a system A transport system inhibitor to perform inhibition experimentsas a system A transport system inhibitor to study its effect on the generation of epileptiform field potentials (EFPs) in the acutely disinhibited cortical slicesas an N-acetyltransferase (SNAT) inhibitor in Hank′s balanced salt solution (HBSS) to study its influence on the uptake of ¹⁴C-cysteine/ radioactive-labeled cysteine

Biochem/physiol Actions

α-(Methylamino)isobutyric acid (MeAIB), a competitive inhibitor of the neutral amino acid transport A system, is an N-methylated substrate. It is capable of decreasing the amplitude of the miniature excitatory postsynaptic current (mEPSC) in hippocampus neurons developing on top of astrocytes. MeAIB can block the alanine-proline (AP) pathway.

Packaging

1 g in poly bottle

250 mg in poly bottle