Application

Mefloquine hydrochloride has been used:to treat cochlear organotypic cultures with various doses to evaluate its role in cellular pathway involved in apoptosisin screening for in vitro antischistosomal activityin cytotoxicity assay of glioblastoma cells

Biochem/physiol Actions

Mefloquine is broadly used as an antimalarial drug. It inhibits 80S ribosomes of Plasmodium. It has numerous side effects like anxiety, dizziness, tremor, headache, and hearing loss. Mefloquine damages cochlear and vestibular hair cells through apoptosis. It also damages spiral ganglion neurons, degenerates cortical neuron and disrupts neuronal calcium homeostasis.

Blocker of gap junction channels Cx36 and Cx50.

Packaging

100 mg in glass bottle