Application

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride has been used to establish the Parkinson′s disease (PD) model in animals.

Biochem/physiol Actions

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a piperidine derivative and dopaminergic neurotoxin, useful in neurological research. MPTP is metabolized to 1-methyl-4-phenylpyridine (MPP+), which in turn can cause free radical production in vivo and lead to oxidative stress. Thus MPP+ is generally acknowledged as the active metabolite of MPTP. MPTP is widely used in in vivo research studies as a model for Parkinsonism. A review describes the application of MPTP in studies related to programmed cell death in neurogenerative diseases.

Dopaminergic neurotoxin.

Packaging

10, 100 mg in serum bottle

Warning

Reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.