L4894-5MG Display Image

Lactoferrin from human milk, powder, BioReagent, suitable for cell culture

Code: L4894-5MG D2-231

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much highe...

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£80.70 5MG
List Price

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Packaging

5, 25, 100 mg in glass bottle

Quality Level200
storage temp.2-8C
product lineBioReagent
solubilityPBS, pH 7.4: 1 mg/mL, clear to slightly hazy (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4, at 25 C)
colorwhite to light red
formpowder
Gene Informationhuman ... LTF(4057)
assay85% (SDS-PAGE)
application(s)cell culture | mammalian: suitable
mol wt82.4 kDa

Code
Description
Unit Size
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L4894-100MG
Unit:100MG
List Price: £863.00
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L4894-25MG
Unit:25MG
List Price: £324.00
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