L3794-10UG Display Image

LOK (1-348), active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SDS-PAGE), buffered aqueous glycerol solution

Code: L3794-10UG D2-231

Biochem/physiol Actions

Mutations in LOK (lymphocyte-oriented kinase) are linked with the anti-apoptotic effects leading to carcinogenesis. It functions as an ERM (ezrin-radi...

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£363.36 10UG
List Price

Biochem/physiol Actions

Mutations in LOK (lymphocyte-oriented kinase) are linked with the anti-apoptotic effects leading to carcinogenesis. It functions as an ERM (ezrin-radixin-moesin) kinase and thereby regulates cytoskeletal organization and lymphocyte migration. It can phosphorylate PLK1 (polo-like kinase 1).

General description

LOK (lymphocyte-oriented kinase) belongs to the Ste20 (sterile 20) family of serine/threonine kinases. It is expressed in lymphocytes, brain, colon, thymus, kidney, liver, small intestine and lung. LOK is commonly referred to as STK10 (serine/threonine protein kinase 10).

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

shipped indry ice
mol wt~65 kDa
Quality Level100
assay70% (SDS-PAGE)
gradePRECISIO Kinase
formbuffered aqueous glycerol solution
Gene Informationhuman ... STK10(6793)
activity2-4 nmol/min·mg
recombinantexpressed in baculovirus infected Sf9 cells
storage temp.70C