Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Western Blotting (1 paper)
Leptin is a hormone secreted by adipocytes and regulates energy homeostasis, inflammation and neuroendocrine processes, synaptic formation and memory condensation. The physiological effects of leptin are mediated by leptin receptors, ObR and LepR. Leptin is the key regulator of obesity and acts directly on neuronal networks to regulate feeding, metabolism, gastric mobility and energy homeostasis. The pathways that mediate the effect of leptin are JAK/STAT, PI3K and JNK.
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synthetic peptide corresponds to the amino terminal (amino acid residues 22-40) of human/mouse leptin.
Solution in phosphate buffered saline containing 1% bovine serum albumin and 15 mM sodium azide.
The antibody is affinity isolated on peptide-agarose.