L2670-10UG Display Image

LYN B, active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SDS-PAGE), buffered aqueous glycerol solution

Code: L2670-10UG D2-231

Biochem/physiol Actions

LYN (proto-oncogene) belongs to the src family of tyrosine kinases. It controls cancer cell growth, migration, invasion and survival. Upregulation of ...

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£363.36 10UG
List Price

Biochem/physiol Actions

LYN (proto-oncogene) belongs to the src family of tyrosine kinases. It controls cancer cell growth, migration, invasion and survival. Upregulation of LYN is associated with shorter overall survival in breast cancer. LYN shows anti- or pro-apoptotic effects. It can enhance AKT (v-akt murine thymoma viral oncogene homolog) phosphorylation or suppress AKT activation. It is also responisble for activation of p58 PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase). Activation of LYN-PI3K-AKT signaling enhances myeloma proliferation.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

mol wt~85 kDa
Quality Level200
shipped indry ice
Gene Informationhuman ... LYN(4967)
assay70% (SDS-PAGE)
gradePRECISIO Kinase
formbuffered aqueous glycerol solution
recombinantexpressed in baculovirus infected Sf9 cells
storage temp.70C
activity205-277 nmol/min·mg