L1294-1G Display Image

Lactoferrin human,;, recombinant, expressed in rice, Iron saturated, >=90% (SDS-PAGE)

Code: L1294-1G D2-231

Application

Lactoferrin was used to grow Streptococcus mutans in an iron-limiting medium. It was used to test if lactoferrin impedes epithelial cell adhesion in ...

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£719.00 1G
List Price

Application

Lactoferrin was used to grow Streptococcus mutans in an iron-limiting medium. It was used to test if lactoferrin impedes epithelial cell adhesion in vitro.

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Packaging

100 mg in poly bottle

1 g in poly bottle

Quality Level200
impurities10 EU/mg endotoxin
typefor cell culture
storage temp.2-8C
recombinantexpressed in rice
biological sourcehuman
formpowder
application(s)microbiological culture: suitable
assay90% (biuret)
assay90% (SDS-PAGE)

Code
Description
Unit Size
List Price
Qty
L1294-100MG
Unit:100MG
List Price: £129.00
Source:List Price
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