L1168-1VL Display Image

Anti-phospho-5-Lipoxygenase (pSer523) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution

Code: L1168-1VL D2-231

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)

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Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)

Biochem/physiol Actions

The gene ALOX5 (arachidonate 5-lipoxygenase) encodes a lipoxygenase that catalyzes the conversion of arachidonic acid (AA) and other fatty acids to bioactive compounds, such as 5(S)-hydroxyeicosatetraenoic acid (5-HETE), leukotriene B4 (LTB4), and other leukotrienes. These leukotrienes and lipoxins function as mediators of inflammatory response. ALOX5 has been implicated in tumorigenesis and may serve as a potential therapeutic target and biomarker.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The gene ALOX5 (arachidonate 5-lipoxygenase), also referred to as 5-LOX (5-lipoxygenase), encodes a protein belonging to the lipoxygenase family. The gene is mapped to human chromosome 10q11.21. The protein contains a distinct ‘;C2-like’; domain at the amino terminal that is involved in Ca2+-dependent membrane binding and a large catalytic domain containing the non-heme catalytic iron. It is highly unstable with short-lived activity.

Immunogen

phosphopeptide corresponding to amino acid residues surrounding the pSer523 of human 5-lipoxgenase (5-LO).

Physical form

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol.

Quality Level200
clonepolyclonal
antibody formaffinity isolated antibody
application(s)immunoprecipitation (IP): suitable
application(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
application(s)western blot: 1:1,000
application(s)indirect immunofluorescence: suitable
species reactivityhuman, rat
storage temp.−20°C
shipped inwet ice
antibody product typeprimary antibodies
biological sourcerabbit
conjugateunconjugated
formbuffered aqueous glycerol solution
Gene Informationhuman ... ALOX5(240)

rat ... Alox5(25290)

UniProt accession no.P09917