Biochem/physiol Actions

Leukemia inhibitory factor (LIF) is a pleotrophic glycoprotein that belongs to the IL-6 family of cytokines. It is secreted by many cell types such as, fibroblasts, macrophages, T cells, monocytes, liver cells, osteoblasts and cells of endometrium. A variety of signal transduction pathways are triggered in response to LIF including ERK/MAPK, JAK1, PI3K, STAT3, Jun-c Fos and NF-κB. The various functions of LIF include proliferation of adult human T cells, maintenance of pluripotency of embryonic stem cells and inhibition of leukemic cell differentiation.

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Immunogen

purified, E. coli-derived recombinant human leukemia inhibitory factor.

Physical form

Lyophilized from a 0.2 µm filtered solution in phosphate buffered saline with 5% trehalose.