Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

Latexin (LXN) is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) in mammals. It functions as a global inhibitor of vertebrate A/B MCPs. Mammalian latexin was recognized as a marker of neurons in the lateral neocortex of the developing brain. The protein has been crucial in the determination of the mechanism of cortical regional specification. It has been implicated in the modulation of sensory perception. It is induced in acute pancreatitis and lung inflammatory disease, which suggests its role in inflammation and innate immune pathways.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

The gene LXN (latexin) encodes a 222-residue that contains two topologically equivalent subdomains with an α-helix surrounded by a curved β-sheet. A third α-helix forms a connection linking the subdomains. It is also called as tissue or endogenous carboxypeptidase inhibitor (CPI) and is predominantly expressed in the heart, prostate, ovary, kidney, pancreas, and colon and to some extent in the brain. The encoded protein is larger than plant and parasite CPIs and does not contain the conserved 7-residue C terminus that is present in the shorter CPIs. This indicates that the mechanism of CPA inhibition varies between latexin and plant/parasite CPIs. The gene is mapped to human chromosome 3q25.32.

Immunogen

Latexin recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST71482.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide