C3912-50MG Display Image

8-(4-Chlorophenylthio)adenosine 3,5-cyclic monophosphate sodium salt, >=97.0% (HPLC), powder

Code: C3912-50MG D2-231

Application

8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt has been used:to upregulate cellular cholesterol pump (adenosine triphosphate- (ATP-) bindi...


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£136.00 50MG
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Application

8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt has been used:to upregulate cellular cholesterol pump (adenosine triphosphate- (ATP-) binding cassette (ABC) transporter-1, ABCA-1)in glucose production assayto stimulate cystic fibrosis transmembrane conductance regulator (CFTR) channel in airway epithelia

Biochem/physiol Actions

Membrane permeable cAMP analog. Used as a selective activator of cAMP dependent protein kinase (PKA). Inhibits cGMP-dependent phosphodiesterase and, at higher concentrations, inhibits cAMP-dependent phosphodiesterase. Inhibits phosphoinositide hydrolysis and secretion stimulated by n-formyl-Met-Leu-Phe but not platelet-activating factor in leukocytes. Renders HL-60 cells more resistant to NO-induced DNA damage.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

10 mg in glass bottle

50, 100 mg in poly bottle

assay≥97.0% (HPLC)
colorwhite
formpowder
Gene Informationhuman ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
InChI keyYIJFVHMIFGLKQL-DNBRLMRSSA-M
InChI1S/C16H15ClN5O6PS.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-;/m1./s1
Quality Level200
SMILES string[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12
solubilityH2O: 25 mg/mL
storage temp.−20°C
Code
Description
Unit Size
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Qty
C3912-100MG
8-(4-Chlorophenylthio)adenosine 3,5-cyclic monophosphate sodium salt, >=97.0% (HPLC), powder

Unit:100MG
List Price: £251.00
Source:List Price
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C3912-10MG
8-(4-Chlorophenylthio)adenosine 3,5-cyclic monophosphate sodium salt, >=97.0% (HPLC), powder

Unit:10MG
List Price: £47.00
Source:List Price
ADD
Cas Number93882-12-3
This product has met the following criteria: