Application

Brefeldin A has been shown to increase CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.

Biochem/physiol Actions

Brefeldin A has been shown to increase CRISPR-mediated homology-directed repair (HDR) efficiency.

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC^®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

General description

Chemical structure: macrolide

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Packaging

5, 25 mg in glass bottle