B7651-25MG Display Image

Brefeldin A, from Penicillium brefeldianum, >=99% (HPLC and TLC)

Code: B7651-25MG D2-231

Application

Brefeldin A has been shown to increase CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.

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£746.67 25MG
List Price

Application

Brefeldin A has been shown to increase CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.

Biochem/physiol Actions

Brefeldin A has been shown to increase CRISPR-mediated homology-directed repair (HDR) efficiency.

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

General description

Chemical structure: macrolide

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Packaging

5, 25 mg in glass bottle

Quality Level300
InChI keyKQNZDYYTLMIZCT-KQPMLPITSA-N
antibiotic activity spectrumneoplastics
SMILES stringC[C@H]1CCCC=C[C@@H]2C[C@H](O)C[C@H]2[C@H](O)C=CC(=O)O1
storage temp.2-8°C
solubilityDMSO: 10 mg/mL
Mode of actionprotein synthesis | interferes
assay≥99% (HPLC and TLC)
InChI1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
biological sourcePenicillium brefeldianum

Code
Description
Unit Size
List Price
Qty
B7651-5MG
Unit:5MG
List Price: £181.00
Source:List Price
ADD
Cas Number20350-15-6
Hazard Class6.1
Un Number2811
Pack Group3