Brefeldin A has been shown to increase CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.
Brefeldin A has been shown to increase CRISPR-mediated homology-directed repair (HDR) efficiency.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Features and Benefits
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Chemical structure: macrolide
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5, 25 mg in glass bottle