B7651-25MG Display Image

Brefeldin A, from Penicillium brefeldianum, >=99% (HPLC and TLC)

Code: B7651-25MG D2-231

Application

Brefeldin A has been shown to increase CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.


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£807.00 25MG
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Application

Brefeldin A has been shown to increase CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.

Biochem/physiol Actions

Brefeldin A has been shown to increase CRISPR-mediated homology-directed repair (HDR) efficiency.

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

General description

Chemical structure: macrolide

Packaging

5, 25 mg in glass bottle

antibiotic activity spectrumneoplastics
assay≥99% (HPLC and TLC)
biological sourcePenicillium brefeldianum
formpowder
InChI keyKQNZDYYTLMIZCT-KQPMLPITSA-N
InChI1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
mode of actionprotein synthesis | interferes
Quality Level300
SMILES stringC[C@H]1CCCC=C[C@@H]2C[C@H](O)C[C@H]2[C@H](O)C=CC(=O)O1
solubilityDMSO: 10 mg/mL
storage temp.2-8°C
Code
Description
Unit Size
List Price
Qty
B7651-5MG
Brefeldin A, from Penicillium brefeldianum, >=99% (HPLC and TLC)

Unit:5MG
List Price: £205.00
Source:List Price
ADD
Cas Number20350-15-6
Hazard Class6.1
Un Number2811
Pack GroupIII
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