B7263-1G Display Image

N-tert-Butyl-alpha-phenylnitrone, >=98% (GC)

Code: B7263-1G D2-231

Application

N-tert-Butyl-a-phenylnitrone has been used:• as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from h...

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£60.50 1G
List Price

Application

N-tert-Butyl-a-phenylnitrone has been used:• as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cells• as a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell lines• to attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)

Biochem/physiol Actions

N-tert-butyl-a-phenylnitrone (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy. The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100Å g).

Packaging

1, 5 g in glass bottle

InChI keyIYSYLWYGCWTJSG-XFXZXTDPSA-N
InChI1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
colorwhite
formpowder
solubilityDMSO: soluble
mp73-74 °C (lit.)
assay≥98% (GC)
storage temp.−20°C
SMILES stringCC(C)(C)[N+]([O-])=Cc1ccccc1
Quality Level100

Code
Description
Unit Size
List Price
Qty
B7263-5G
Unit:5G
List Price: £199.00
Source:List Price
ADD
Cas Number3376-24-7