Biochem/physiol Actions

Foxh1 is a transcriptional activator. Foxh1 can recognizes and binds to the DNA sequence 5′-TGT[GT][GT]ATT-3′ and is required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Foxh1 forms a transcriptionally active complex containing FAST-1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).

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General description

Forkhead box protein H1 (FOXh1) also known as FAST-1 contains a DNA binding TGT(G/T) motif which it uses to bind SMAD2 and regulate transcription.

Immunogen

Synthetic peptide directed towards the middle region of mouse FOXH1

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: GPSSSSETPLWPLCSLPGPTIIEGESSQGEVIRPSPVTPDQGSWPLHLLE