Application

Alamethicin fromTrichoderma viride has been used:to examine the effect of glutamate transporters on the Na⁺/K⁺-ATPase dependent extracellular K⁺ transient during neuronal activityto investigate the formation of anion-permeable channels in planar lipid bilayers by magainin I obtained from Xenopus skinto study the permeability of root apical meristem and epidermis and cellulase induced resistance to Alamethicin in Arabidopsis thalianato study the cytotoxic effects of the phycotoxin okadaic acid and mycotoxins on human intestinal (HT-29) and neuroblastoma (SH-SY5Y) cell linesto analyze the structural variations and biological activity of peptaibols obtained from the Longibrachiatum clade belonging to the genus of filamentous fungi Trichoderma

Biochem/physiol Actions

Alamethicin is responsible for eliciting resistance in plants and is harmful to them by causing lesions and rapid death associated with ribosomal ribonucleic acid (rRNA) cleavage. It can cause permeability of the apical meristem and epidermis in A. thalianaroots. Alamethicin leads to the coiling of tendrils in Bryonia dioica induced by jasmonates.

General description

Alamethicin is an antibiotic and a cytolytic peptide capable of forming an amphipathic α-helical structure in biological membranes. It is a linear peptaibol, made up of 20 amino acid residues. It belongs to the class of Nonribosomalpeptides(NRP)and is loaded with alpha-amino isobutyric acid.

Packaging

5, 10, 25 mg in glass bottle

Quality

A mixture of alamethicin homologs

Sequence

Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Glu(NH₂)-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Glu(NH₂)-phenylalaninol