Application

Reactant for:Preparation of deprotecting agents in preparation of cellulose derivativesSynthesis of lipophilic peptides for DNA transfections in vivoDehydrobromination reactions

Tetrabutylammonium fluoride trihydrate can be used as a base:For the dehydrobromination of vinyl bromides to terminal acetylenes.In the conversion of 1,1-dibromo-1-alkenes to terminal alkynes via Corey–Fuchs reaction.In Hiyama cross-coupling reaction of aryl and heteroaryl chlorides with aryltrialkoxysilanes in the presence of a palladium catalyst.It can be used to catalyze ethynylation of quinolines and isoquinolines using calcium carbide in aqueous N,N-dimethylacetamide.

General description

Tetrabutylammonium fluoride trihydrate is a mild base used in reactions like aldol-type condensation reactions, Michael-type reactions, ring-opening reactions. Its is also used as a promoter in cross-coupling reactions and cyclization of carbocycles and heterocycles.

Other Notes

Reagent for the cleavage of silyl ethers and other silyl protecting groups; Catalyst for various reactions with silicon compounds; Use as a base in organic synthesis; Instability of anhydrous TBAF

Packaging

10, 50, 250 g in poly bottle