Reagent for Selective MetalationsUsed for:• Preparation of functionalized acyclic alkenyl magnesium reagents/preparation of 1,2-diketones• Preparation of cyclic alkenyl and dienyl magnesium reagents• Preparation of functionalized triazenes/preparation of carbazoles• Regioselective functionalization of trisubstituted pyridines• Electrophilic amination for preparation of amines• Preparation of Grignards reagents in the presence of masked ketones and aldehydes (using readily deprotectable silylated cyanohydrins)• Preparation of Benzylic Grignards via Sulfur-Magnesium exchange• Functionalization via I-Mg Exchange of unprotected aromatic and heteroaromatic carboxylic acids• Functionalization via I-Mg Exchange of unprotected imidazoles• Pyridyne formation• Functionalization of cyclopentene derivatives• Preparation of 2,3-functionalized furans, benzofurans, and thiophenes• Stereoselective synthesis of substituted cyclopropanes
Reagent used with CH3MgCl/LiCl to affect magnesium-halogen exchange on unprotected aryl carboxylic acids.
Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
Product of Albemarle US Inc
4×25, 100, 800 mL in Sure/Seal™
2 L in Sure/Seal™
The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.