Application

Reagent for Selective MetalationsUsed for: Preparation of functionalized acyclic alkenyl magnesium reagents/preparation of 1,2-diketones Preparation of cyclic alkenyl and dienyl magnesium reagents Preparation of functionalized triazenes/preparation of carbazoles Regioselective functionalization of trisubstituted pyridines Electrophilic amination for preparation of amines Preparation of Grignards reagents in the presence of masked ketones and aldehydes (using readily deprotectable silylated cyanohydrins) Preparation of Benzylic Grignards via Sulfur-Magnesium exchange Functionalization via I-Mg Exchange of unprotected aromatic and heteroaromatic carboxylic acids Functionalization via I-Mg Exchange of unprotected imidazoles Pyridyne formation Functionalization of cyclopentene derivatives Preparation of 2,3-functionalized furans, benzofurans, and thiophenes Stereoselective synthesis of substituted cyclopropanes

Reagent used with CH₃MgCl/LiCl to affect magnesium-halogen exchange on unprotected aryl carboxylic acids.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Product of Albemarle US Inc

Packaging

4×25, 100, 800 mL in Sure/Seal™

2 L in Sure/Seal™

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.