569396-100UG Display Image

INSOLUTION(TM) STAUROSPORINE; STREPTOMYCES SP.

Code: 569396-100UG D2-231

Biochem/physiol Actions

Reversible: yes

Product competes with ATP.

Target IC50: 7 nM, 20 nM, 1.3 nM, 700 pM, 8.5 nM, against protein kinase A , CaM kin...


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Your Price
£177.00 100UG

Biochem/physiol Actions

Reversible: yes

Product competes with ATP.

Target IC50: 7 nM, 20 nM, 1.3 nM, 700 pM, 8.5 nM, against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively

Cell permeable: yes

Primary TargetPKA

General description

A potent, cell-permeable broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Couldwell, W.T., et al. 1994. FEBS Lett.345, 43.Nishimura, H. and Simpson, I.A. 1994. Biochem. J.302, 271.Bruno, S., et al. 1992. Cancer Res.52, 470.Kiss, Z. and Deli, E. 1992. Biochem. J.288, 853.Vitale, M.L., et al. 1992. Neuroscience51, 463.Hoffman, R. and Newland, E.S. 1991. Cancer Chemotherap. Pharmacol.28, 102.Oka, S., et al. 1986. Agric. Biol. Chem.50, 2723.

Packaging

Packaged under inert gas

100 µg in Plastic ampoule

Physical form

A 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO.

Reconstitution

Following initial thaw, aliquot, purge with inert gas, and freeze (-70°C).

Warning

Toxicity: Irritant (B)

assay≥97% (HPLC)
formliquid
InChI keyHKSZLNNOFSGOKW-FYTWVXJKSA-N
InChI1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inwet ice
storage conditionprotect from light, OK to freeze
storage temp.−70°C
Cas Number62996-74-1
Quantity
Est. Dispatch/Availability