General description

A fluoroquinolone antibacterial compound that displays antitumor properties. Shown to bind to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP; K_d = 12.56 µM), enhance RNAi and stimulate miRNA expression. Specifically induces cell-cycle arrest and apoptosis in a panel of 12-cancer cells (EC₅₀ of 124 µM in HCT-116 cells) and suppresses tumor growth in a xenograft mouse model (10 mg/kg, i.p.).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Melo, S., et al. 2011. Proc. Natl. Acad. Sci. USA108, 4394.Zhang, Q., et al. 2008. Cell Res.18, 1077.Shan, G., et al. 2008. Nat. Biotechnol.26, 933.

Packaging

250 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.

Warning

Toxicity: Standard Handling (A)