General description

A non-interferon-inducing, broad spectrum antiviral nucleoside. Reported to be active against RSV, HIV, HCV, and other infectious agents. Its metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.

A non-interferon-inducing, broad spectrum antiviral nucleoside that is active against RSV, HIV, HCV and other infectious agents. Inhibits the growth of human myeloma 8226 cells (IC₅₀ = 40 µM) and ovarian carcinoma OVCAR-5 cells (IC₅₀ = 35 µM). Its metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase. Antiviral effects of Ribavirin can be reversed by depriving infected cells of methionine or isoleucine.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Li, W., et al. 1999. Oncol. Res.11, 243.Honda, Y., et al. 1994. Antimicrob. Agents Chemother.38, 653.Liao, H.J. and Stollar, V. 1993. Antiviral Res. 22, 285.Kakumu, S., et al. 1993. Gastroenterology105, 507.Sidwell, R.W., et al. 1979. Pharmacol. Ther.6, 123.

Packaging

10 mg in Glass bottle

Warning

Toxicity: Carcinogenic / Teratogenic (D)