Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetDAG lipase

Target IC₅₀: 4 nM against DAG lipase activity in canine platelets

General description

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II and ATP-induced synthesis of 6-keto-prostaglandin F1α.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295.Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.Konrad, R.J., et al. 1994. Biochemistry 33, 13284.Mason-Garcia, M., et al. 1992. Am. J. Physiol.262, C1197.Balsinde, J., et al. 1991. J. Biol. Chem.266, 15638.

Packaging

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)