Application
Tetrodotoxin, Fugu sp., CAS 18660-81-6, is a reversible blocker of Na+ channels. Inhibits the release of glutamate via Na+-dependent glutamate transporter.
Biochem/physiol Actions
Target IC50:63 nM Iinhibiting the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation
General description
Reversibly blocks Na+ channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na+ channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation (IC50 = 63 nM).
Reversibly blocks Na+ channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na+ channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation (IC50 = 63 nM).
Other Notes
Not available for sale outside of the United States.
Packaging
1 mg in Alu drum
Physical form
Crystalline solid. Contains sodium citrate.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Activity is destroyed if exposed to alkaline or strongly acidic conditions.
This product has met the following criteria: